Xenbase Image ID: 137171

Figure 3. Abnormal stratification and decreased mRNA level of secretory protein in the Bmpr1a-CKO mutant prostate. A, Control AP ducts at P28. B, Bmpr1a-CKO mutant AP at P28. C, Histologic section of the control prostate. Inset, Luminal cells (red arrowhead) and basal cells (black arrow) were observed. D, Histology of the Bmpr1a-CKO mutant prostate. Inset, Abnormally stratified epithelia were observed (black arrowhead). Scale bars, 100 μm. E, Probasin mRNA expression was decreased in the mutant AP at P28. The relative RNA equivalents for each sample were normalized by the RNA levels for ribosomal protein L8. Error bars represent the mean ± SE of 7 tissue samples. Statistical significance was indicated by an asterisk. F and G, Expression of K8 in control (F) and mutant (G) prostate. K8-positive basal side epithelia were indicated (G, black arrow). H and I, Expression of K14 in control (H) and mutant (I) prostate. K14-positive luminal side epithelia were indicated (I, black arrow). Increased levels of K8 (G) and K14 (I) were detected in the Bmpr1a-CKO mutants at P49. Scale bars, 20 μm. Image published in: Omori A et al. (2014) Copyright © 2014 by the Endocrine Society. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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