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Figure 6. Stromal hyperplasia and inflammation with enlarged epithelial nuclear structures were observed in the Bmpr1a-CKO mutants. A, Morphology of AP in wild-type, ShhCreERT2/+;Bmpr1a-flox/+ (Control), and ShhCreERT2/+; Bmpr1a-flox/− mice at 6 months of age. B, D, and G, Histology of control AP. C, E, F, H, and I, The sections of the epithelial-specific Bmpr1a-CKO mutant AP. B–I, Sections stained with hematoxylin and eosin showed inflammatory cells in the stroma (E), stromal hyperplasia (F, black arrow head), inflammatory cells (H, black arrows), and enlarged nuclear structures (I) in the AP of Bmpr1a-CKO mice. A and B, Scale bars, 200 μm. D–F, Scale bars, 20 μm. Image published in: Omori A et al. (2014) Copyright © 2014 by the Endocrine Society. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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