Xenbase Image ID: 137349

Figure 1. miR-34/449 TKO mice exhibit defective mucociliary airway clearance and infertilitya. Gene structure (top) and sequence alignment (bottom) of mouse miR-34/449 miRNAs. Red box: seed sequences. b. TKO mice exhibit frequent postnatal mortality. Log-rank test. c. Surviving TKO mice display postnatal growth retardation. d. Excessive mucus accumulation and infection in paranasal sinuses of dying TKO at P7 (top) and surviving adult TKO mice (bottom). Arrow: infection; arrowhead: mucus accumulation; n=15. e. Adult TKO males and females are infertile. Although early spermatids (Sd) are developed, few intact spermatozoa (Sz) are generated (top, n=3). A significant MCC reduction is observed in TKO fallopian tubes (bottom, n=3). Image published in: Song R et al. (2014) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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