Xenbase Image ID: 137351

Figure 3. miR-34/449 deficiency causes defective basal body docking in mouse airway MCCsa. TKO tracheas exhibit ciliation defects, shown by immunofluorescence staining for Ac-α-tub (cilia) and γ-tubulin (basal bodies). a: fully, b: partially, c: non ciliated MCC; n=3. b, c, d. Basal bodies fail to dock to the apical membrane of TKO MCCs. b. Lateral projections of confocal micrographs shown in (a) c. Transmission electron microscopy (TEM) confirms basal body docking defects in TKO MCCs. n=3. d. Quantification of basal body docking based on TEM studies in (c). Docked and undocked basal bodies exhibit a distance ≤ 0.3 μm and > 0.3 μm to the apical membrane, respectively. Error bar, s.e.m. Image published in: Song R et al. (2014) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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