Xenbase Image ID: 137410

Figure 3. Comparison of single-cell proteomes and transcriptomes. (A) Scatterplot of the mean protein and mRNA levels for genes quantified in all individual proteomes and transcriptomes (4798 genes) reveals a poor correlation between protein and mRNA abundance. (B) Unsupervised correlation-based clustering of global proteomes (left panel) and transcriptomes (right panel) indicate tight regulation of global proteome and transcriptome. (C) Scatterplot of protein and mRNA CV (4798 genes) reveals a lack of correlation between protein and mRNA variation. Genes are colored that show similar mRNA and protein variation (green, high variation; blue, low variation) and that show differential mRNA and protein variation (red, low protein and high mRNA variation; orange, high protein and low mRNA variation). Genes outside these categories are in black. (D) Enriched GO terms for the gene groups as depicted in C. Y-axis represents the –log FDR. See also Supplementary Table S4. Image published in: Smits AH et al. (2014) © The Author(s) 2014. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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