Xenbase Image ID: 137436

Figure 6. Hierarchical Sequence of Events of Transcriptional Reprogramming by the Xenopus OocyteStages of nuclear reprogramming by the Xenopus oocyte. After NT to the Xenopus oocyte, somatic nuclei are bound by oocyte-specific B4. Loss of somatic Pol II and TBP starts. B4 binding is followed by the accumulation of oocyte-specific TBP2 and hypophosphorylated RPB1 (Pol II binding) derived from the oocyte, which becomes subsequently phosphorylated on serine 5. This is followed by serine 2 phosphorylation, resulting in productive transcription. The same ordered sequence of events takes place in most of transplanted nuclei within 48 hr, with slightly different kinetics. Image published in: Jullien J et al. (2014) Image downloaded from an Open Access article in PubMed Central. © 2014 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society Larger Image Printer Friendly View

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