Xenbase Image ID: 137544

Figure 1. Predicted amino acid sequence alignments of Ink4d proteins. The predicted amino acid sequences of Ink4d proteins from Xenopus tropicalis, Fugu (Fugu rubrides), mouse (Mus musculus) and human (Homo sapiens) were compared to the two Ink4d proteins of Xenopus laevis. The Xl-Ink4d1 cDNA was isolated from a library made from Xenopus laevis adult spleen, whereas Xl-Ink4d2 was identified by blasting the NCBI database for similar expressed sequences in Xenopus laevis and represents a second allele of Ink4d. Xl-Ink4d1 protein shares 63% amino acid identity with both the human and mouse Ink4d protein. The predicted four ankyrin repeats (green lines) as well as many of the amino acids that make contacts with CDK6 are conserved between mammals and Xenopus (red box = hydrogen bond interaction, blue box = non-polar interaction). Image published in: Doherty JR et al. (2014) Copyright: © 2014 Doherty JR, et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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