Xenbase Image ID: 137789

Figure 2. NaN3 activates KATP channels heterologously expressed in Xenopus oocytes. (A) Voltage ramp protocol (upper panel) used to elicit whole‐cell currents (lower panel) measured by TEVC. Currents were recorded under control conditions, after 10 min exposure to 3 mmol/L NaN3 and after washout of NaN3. Arrow indicates 0 current level. (B) Time‐dependent changes in the inward current recorded at −80 mV in a single representative oocyte induced by application and subsequent washout of 3 mmol/L NaN3. (C) Bar graphs comparing IKATP measured at −80 and +40 mV during voltage ramps before (control), at peak of NaN3 effect and after washout of NaN3 (n = 10). *P < 0.001 relative to control, #P < 0.001 relative to NaN3‐peak current (one‐way ANOVA and Tukey's multiple comparison test). Image published in: Garg P and Sanguinetti MC (2014) © 2014 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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