Xenbase Image ID: 137998

FIG. 8. SIP1 polypeptides repress endogenous Xbra gene expression in early Xenopus embryos. Xenopus embryos at the 2- to 4-cell stage were left uninjected (A) or were injected with 1 ng of RNA encoding SIP1CZF (B), XOtx2(K3E) (C), or full-length SIP1 (D). Both SIP polypeptides caused repression of Xbra expression. In panels B and D, expression is down-regulated in half the embryo because one of two cells of the early embryo was injected. In a typical experiment, 14 of 16 embryos injected with RNA encoding SIP1CZF displayed down-regulation of Xbra expression, as did, in a separate experiment, 18 of 19 embryos injected with full-length SIP1. Slight down-regulation of Xbra expression was seen in only 1 of 13 embryos injected with RNA encoding Otx2(K3R). Image published in: Verschueren K et al. (1999) Copyright © 1999. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 11 marginal zone mesoderm Image source: Published Larger Image Printer Friendly View

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