Xenbase Image ID: 138125

Figure 5 Partial rescue of eye defects in cnrip1 knockdown embryos. Cnrip1 MO (5 ng) was co-injected with or without myccnrip1 mRNA (350 pg) into the left dorsoanimal blastomere of 8-cell stage embryos. Injected embryos were cultured until stage 37/38. (A) The respective morphologies are shown as lateral views with anterior leftwards and dorsal upwards. (B) Left bar, 64% of embryos injected with cnrip1 MO alone exhibited severe eye defects (absent or very small eyes). Seventy-one embryos were examined in three independent experiments. Right bar, 51% of embryos injected with cnrip1 MO plus myc-cnrip1 mRNA displayed severe eye defects. Ninety-six embryos were examined in three independent experiments. Values are mean SD of the percentages of embryos with severe eye defects from three independent experiments; *P < 0.05. ‘Very small eyes’ include small eyes with a dot-like, crescent, or gibbous shape, but not small eyes with a nearly round shape. Image published in: Zheng X et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, John Wiley & Sons. Experiment + Assay Source Phenotypes and Disease Xla Wt + cnrip1 MO + NF37/38 (morphology) fig.5.a Anatomical Phenotype abnormal anterior-posterior axis morphology abnormally incomplete structure of head absent eye decreased length of anterior-posterior axis decreased size of the eye decreased size of the head Larger Image Printer Friendly View

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