XB-IMG-138200
Xenbase Image ID: 138200
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Fig. 7. A working model illustrating the mechanism by which TRPP2-
dependent Ca2+ signaling controls pax8 expression in the kidney field.
Model is based on present data and previously published results (Cartry
et al., 2006; Leclerc et al., 2008). The present work shows that pax8
expression requires an increase in intracellular Ca2+ concentration [Ca2+]i.
This increase in [Ca2+]i might be due to the incorporation of TRPP2 channel,
possibly under the control of RA signaling. We propose that RA is able to
induce a [Ca2+]i in the kidney field, as it does in embryo explants (Leclerc
et al., 2008), and then indirectly controls pax8 expression. The mechanism
by which Ca2+ regulates pax8 transcription is still unknown. Image published in: Futel M et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, The Company of Biologists Ltd. Larger Image Printer Friendly View |