Xenbase Image ID: 138471

Fig 2. The nol11 craniofacial phenotype. A) Gross morphology and cartilage staining of UC, nol11 whole embryo, nol11 one-sided knockdowns and CMO one-sided knockdown embryos. Note the reduced cartilage size and abnormal morphology in nol11 morphants (red arrowheads) while CMO injected embryos are unaffected. B) Craniofacial cartilage size is significantly reduced in nol11 but not CMO morphants. C) Co-injection of human NOL11 RNA can rescue the cartilage phenotype in approximately 75% of treated embryos. Cartilage staining of an RNA rescued embryo; nol11 MO was injected at the one cell stage and human NOL11 RNA was injected into one cell at the two cell stage. Green arrowheads highlight rescued side. doi:10.1371/journal.pgen.1005018.g002 Image published in: Griffin JN et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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