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Fig 3. Knockdown of nol11 disrupts cranial neural crest development. At stages 14 and 24 neural and CNC development appears normal in one side treated embryos, as assayed by expression of key marker genes including sox3, cytokeratin, twist and slug. By stage 28 however, reductions are apparent in the expression of numerous CNC genes. The branchial arches are also smaller on the MO treated side at stage 28. Graph displays number of embryos exhibiting abnormal gene expression in control and nol11 morphant embryos. doi:10.1371/journal.pgen.1005018.g003 Image published in: Griffin JN et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue sox3 Sry, Xlsox3, xSox3, Xtsox3 X. tropicalis Throughout NF stage 14 neural plate pre-chordal neural plate chordal neural plate krt12.4 ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. tropicalis Throughout NF stage 14 epidermis sox9 cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. tropicalis Throughout NF stage 28 neural crest cranial neural crest eye retina optic vesicle mandibular crest dlx5 dll3, X-dll3 X. tropicalis Throughout NF stage 28 neural crest cranial neural crest olfactory placode hyoid crest mandibular crest gsc goosecoid, gsc-a, gsc-b, Xgsc X. tropicalis Throughout NF stage 28 neural crest cranial neural crest branchial arch twist1 twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. tropicalis Throughout NF stage 24 neural crest trunk neural crest cranial neural crest migratory neural crest cell hyoid crest twist1 twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. tropicalis Throughout NF stage 28 neural crest cranial neural crest migratory neural crest cell branchial arch twist1 twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. tropicalis Throughout NF stage 14 neural crest cranial neural crest snai2 slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. tropicalis Throughout NF stage 24 cranial neural crest neural crest migratory neural crest cell hyoid crest mandibular crest Image source: Published Larger Image Printer Friendly View

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