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Figure 1. Physiological relevance of SGLT1, GLUT2, and KATP channel in glucose-induced GLP1 secretion in the early phase. Blood glucose (A) and plasma GLP1 concentrations (B) in portal vein at 5 min after intraduodenal administration of glucose (or vehicle) are shown. Glucose was co-administrated with or without phlorizin (500 mg/kg) or phloretin (500 mg/kg) to WT mice (A and B). Blood glucose (C) and plasma GLP1 concentrations (D) in portal vein of Kir6.2-deficient mice at 5 min after intraduodenal glucose administration are also shown. Data are expressed as mean±s.e.m. *P<0.05 and ***P<0.001. Image published in: Lee EY et al. (2015) © 2015 The authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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