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Figure 1. Models for disk membrane morphogenesis. Hypothesis 1: In the endosome model, disk membranes are formed by multiple endosomes fusing to grow into larger disks (Miyaguchi and Hashimoto, 1992; Obata and Usukura, 1992; Chuang et al., 2007). It is unclear when and how the disk rim is formed and if immature disks have rim regions. PM and disk membrane renewal are not necessarily synchronized. Hypothesis 2: In the evagination model, disk membranes are formed by initial PM evagination, which then becomes sealed to generate closed and mature disks (Steinberg et al., 1980). The sealing also results in the generation of the disk rim and the new PM domain. Image published in: Nemet I et al. (2014) Copyright © 2014. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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