Xenbase Image ID: 139635

Figure 6. Model of Smad2/3 and E2a Interactions in Transcriptional Regulation (A) At the lefty locus. In control embryos, Smad2/3 normally occupies region 1, while E2a normally occupies region 2. Transcription of lefty is weak. In the absence of E2a, Smad2/3 moves to preferentially occupy region 2, and transcription of lefty is upregulated. (B) At dorsal mesoderm loci. In control embryos, Smad2/3 occupancy at enhancers is coupled by E2a to coactivators, and transcription of the target gene (epha4 is shown as an example) is robust. In the absence of E2a, the coupling of Smad2/3 to transcriptional coactivators is lost, and transcription of the target gene is reduced. Image published in: Wills AE and Baker JC (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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