Xenbase Image ID: 139689

Fig. 1. ErbB signaling regulates Xenopus gastrulation. (A) ErbB4-specific MO blocks induction of ectopic structures by Xenopus, but not by human, ErbB4. RNAs encoding ErbB4 (1–2 ng), with or without 20 ng ErbB4-MO, were injected into the animal region of two-cell stage embryos. (B) Injection of ErbB4-MO (20 ng) into dorsal marginal zone (DMZ) of four-cell stage embryos induced gastrulation defects. Morphants showed delayed blastopore closure, open back, and axial and head defects. (C) Human ErbB4 (5–8 pg) partially rescued gastrulation defects induced by ErbB4-MO. (D) Rescue of gastrulation defects induced by DN-ErbBs (2–4 ng) with wild-type ErbBs (0.2 ng). In panels C and D, embryos with different phenotypes were counted and summarized in the bar graph. Image published in: Nie S and Chang C (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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