Xenbase Image ID: 139691

Fig. 3. ErbB signaling regulated C&E in DMZ explants. (A) DN-ErbBs blocked DMZ explants elongation. 2 ng RNAs encoding DN-ErbBs or DN-FGFRs were injected into the DMZ regions of four-cell stage embryos. DMZ explants were dissected from gastrula (stage 10) embryos and cultured till neurula stages (stage 17). (B) Unlike DN-FGFRs, DN-ErbBs did not significantly inhibit mesodermal marker expression in DMZ explants. (C) Similarly to DN-ErbBs, ErbB4-MO blocked C&E. The C&E movements were rescued by coexpression of human ErbB4 with ErbB4-MO, or wild-type ErbBs with DN-ErbBs. Image published in: Nie S and Chang C (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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