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Figure 7. Gliclazide reduces MgATP and MgADP activation of Kir6.2-G334D/SUR1. (A and C) Representative records showing activation of Kir6.2-G334D/SUR1 currents by 1 mM MgADP (A) or 10 mM MgATP (C) in the presence and absence of 30 µM gliclazide (as indicated). The dotted lines indicate the zero current level. (B and D) Concentration-activation relationships for MgADP (B) or MgATP (D) for Kir6.2-G334D/SUR1 channels in the absence (open circles; n = 6) or presence (closed circles; n = 6) of 30 µM gliclazide. (B) The lines are the best fit of Eq. 2 to the mean data. Open circles: EC50 = 9 µM, h = 1.3; a was fixed at 1. Closed circles: EC50 = 560 µM, h = 1.5, a = 0.3. (D) The lines are the best fit to the mean data of Eq. 2 with a set to 1 (open circles: EC50 = 124 µM, h = 1.3) or Eq. 2 with a set to 0.3 (closed circles: EC50 = 8.1 mM, h = 1.3). Mean ± SEM. Image published in: Proks P et al. (2014) © 2014 Proks et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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