XB-IMG-139911
Xenbase Image ID: 139911
Fig. 1.
NOTCH receptors. The mammalian NOTCH family has four members NOTCH1-4; all consist of extracellular and intracellular domains. The extracellular domain 29–36 Epidermal growth factor (EGF) like repeats followed by three Lin-NOTCH repeats (LNR). The intracellular domain has the RBP-J-associated molecule (RAM) domain, six ankyrin repeats (ANK), nuclear localization sequences (NLS), a transactivation domain (TAD) required for activating transcription and a proline-, glutamate-, serine- and threonine-rich (PEST) domain which regulates NOTCH degradation. NOTCH1 and NOTCH2 are structurally similar, NOTCH3 and NOTCH4 are smaller proteins as they have fewer EGF repeats and lack TAD Image published in: Suresh S and Irvine AE (2015) Image downloaded from an Open Access article in PubMed Central. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. Larger Image Printer Friendly View |