Xenbase Image ID: 140015

Fig. 7. pax6 mutants display altered forebrain patterning. In situ hybridization comparison of expression patterns of several genes show altered brain patterns in mutant versus wild-type embryos. pax6 mRNA expression is lost from the pretectum (white arrow) and ventral thalamus of mutants, but appears to be maintained normally in more anterior parts of the forebrain including retina at stage 38 (A). By contrast, as seen in panel (B) the expression domain of nkx2-1 appears to be expanded in the telecephalon (white arrow) of pax6 mutants compared to wild-type. gsx2 expression is lost from the prethalamus (C, white arrow) of the mutant, and neurog2 is greatly reduced in the telencephalon (D, white arrow) of mutant embryos. Image published in: Nakayama T et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue pax6 an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. tropicalis Throughout NF stage 37 and 38 eye brain lens retina spinal cord diencephalon optic chiasm optic tract forebrain pretectum gsx2 gsh2 X. tropicalis Throughout NF stage 41 brain telencephalon diencephalon forebrain prethalamus Image source: Published Larger Image Printer Friendly View

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