Xenbase Image ID: 140020

Fig. 12. Xenopus mutants for pax6 exhibit anterior eye defects comparable to those observed in Pax6 mutant mice. Histological sections cut through eyes from either wild-type (Normal) or Pax6 mutant (Mutant) X. tropicalis (Xenopus) and mice (Mouse) showing anterior structures. (A) Wild-type froglet eye. White arrowhead denotes lens epithelial cells. (A′) High magnification view of lens epithelial cells in region of lens adjacent to retina. Dotted line denotes boundary between lens and retina. (B) pax6 Hypomorphic froglet eye. In addition to the eye being smaller, defects in the cornea, iris, and lens are evident. Circle indicates region with likely iridolenticular adhesion. (B′) High magnification view of lens epithelial cells in region of lens adjacent to retina comparable to A′. Dotted line denotes boundary between lens and retina. Note expansion of acellular material between lens and retina compared to wild-type. (C) 8-Week-old adult wild-type mouse (D) 8-week-old adult Pax6Sey-Neu/+ mouse. Black arrowheads denote iridokeratotic adhesion. Open arrowhead denotes iris or ciliary tissues. (D′) Arrow shows iridolenticular adhesion in section cut from different Pax6Sey-Neu/+ mouse. (D′) Arrow shows iris hypoplasia typically observed in these Pax6Sey-Neu/+ mice; this section was cut from a third Pax6Sey-Neu/+ mouse at a plane comparable to that of the wild-type mouse in C. cb, ciliary body; nr, neuroretina. Scale bar in panel A applies to panel B; scale bar in C applies to panel D. Scale bars in A′, B′ and D′ denote 50 μm. Scale bar in D′ denotes 200 μm. Image published in: Nakayama T et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

Return to previous page