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Fig 7. Cooperativity of Nemp1 and Ran in early eye development. A. Spatiotemporal expression of Xenopus ran in the early development. Developmental stages are indicated. (a) Lateral view. (b, c) Dorsal view with the anterior side up. (d) Lateral view with the dorsal side up. opv, optic vesicles; otv, otic vesicles; ba, branchial arches. B. Eye defect phenotypes by knockdown of nemp1 and ran. nemp1MOs (5–20 ng) and n-βxgal mRNA as a tracer (blue) were injected into the animal pole region of a dorsal blastomere at the four cell stage with ranMO or standard control MO (stdMO). Upper panels show eye-defect phenotypes at the tailbud stage (around stage 35) as indicated. The lower bar graph shows percentages of eye defects at tailbud stages. n, the number of embryos examined; exp, the number of independent experiments. Image published in: Shibano T et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue ran.S ara24, gsp1, ran-1, RanTC4, tc4 X. laevis Throughout NF stage 29 and 30 optic vesicle eye otic vesicle neural tube posterior neural tube anterior neural tube head region pharyngeal arch pronephric mesenchyme brain central nervous system spinal cord ran.S ara24, gsp1, ran-1, RanTC4, tc4 X. laevis Throughout NF stage 20 neural tube posterior neural tube anterior neural tube ran.S ara24, gsp1, ran-1, RanTC4, tc4 X. laevis Throughout NF stage 13 neural plate pre-chordal neural plate chordal neural plate ran.S ara24, gsp1, ran-1, RanTC4, tc4 X. laevis Throughout NF stage 3 (4-cell) animal pole animal animal blastomere Image source: Published Larger Image Printer Friendly View

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