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Figure 9. Xfz5 Governs Neural Potential during Retinal Development (A) During normal development, Xfz5 regulates the expression of Sox2 in retinal progenitors, allowing progenitors to proliferate, express proneural genes, and ultimately differentiate into postmitotic retinal neurons. (B) When Xfz5 function is blocked, Sox2 expression is reduced in retinal progenitors, resulting in reduced proliferation, loss of proneural gene expression, and a bias toward the nonneural Mu¨ller glial fate. Image published in: Van Raay TJ et al. (2005) Copyright © 2005. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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