Xenbase Image ID: 144527

Figure 5. Both Membrane-Targeted and Constitutively Cytoplasmic Dishevelled Are Potent Activators of Canonical Wnt Signaling (A) Injection of 50 pg Xdsh-MA or Dvl-KM-caax is sufficient to induce secondary axes when injected ventrally into 8-cell Xenopus embryos. Injection of equivalent doses of wild-type Xdsh-GFP or Dvl-1 fails to induce secondary axes. Many of the secondary axes induced by Dvl- KM-caax or Xdsh-MA were complete, as judged by the presence of a secondary cement gland (B, arrow). (C) Injection of 50 pg Xdsh-MA or Dvl-KM-caax in animal caps is sufficient to activate transcription of the direct Wnt target genes Xnr-3 and siamois. Injection of equivalent doses of wild-type Xdsh-GFP or Dvl-1 fails to activate transcription of these genes. Image published in: Park TJ et al. (2005) Copyright © 2005. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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