Xenbase Image ID: 144611

Figure 7. XGAP and PAR Proteins Are Mutually Required for the Intracellular Localization (A) XGAP regulates the localization of xPAR-6 and xPKCλ proteins. Venus-tagged xPAR-6 or xPKCλ was coinjected with or without XGAP-Mo into two blastomeres to destine them to the animal cap or DMZ. The XGAP-MO phenotype in DMZ was rescued by resXGAP. The horizontal plane is the mediolateral axis. The insets show the disruption of their polarized localization even in the XGAP-Mo-injected cells with spindle-shape morphology like Figure 3A. (B) xPAR-6 and xPKCλ are required for the polarized localization of XGAP. Venus-tagged XGAP was coinjected with xPAR-6 Mo or xPKCλKE and fated to DMZ. The membrane bound RFP was also injected to mark the cell membrane. The horizontal plane is the mediolateral axis. Image published in: Hyodo-Miura J et al. (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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