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Figure 2. Rapid degeneration of cochlear hair cell bundles in DBA/2J mice. In the basal turn of the cochlea, bundles of outer hair cells (OHCs) and inner hair cells (IHCs) of DBA/2J mice (2J) appeared normal at 2 weeks of age ( a ), but at 1 month ( b ) and 3 months ( c ) of age, most OHC bundles already showed signs of degeneration, and some were missing (indicated by asterisks). By 6 months of age in the base ( d ), all OHCs were missing and the few remaining IHCs had degenerated bundles (indicated by arrow); in the middle turn ( e ), bundles were severely disheveled (arrowhead) and often had lost most rows of stereocilia (arrow). In contrast, all OHC and IHC bundles of the control DBA/2NCrl mice (2NCrl) at 3 months ( g ) and 6 months ( f , h ) of age appeared normal, and only a few OHC bundles were missing (asterisks in h ); the bundles of the remaining OHCs appeared normal. A fourth row of OHCs was seen at frequent intervals throughout the length of the cochlea in both DBA/2J and DBA/2NCrl mice (indicated by arrow in h ). Panel widths: a–d , g , h , 29 μm; e , f , 7.3 μm. Image published in: Shin JB et al. (2010) Copyright © 2010. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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