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Figure 14. Proposed model for the emergence of craniofacial muscle stem cells: the bi-potential head mesodermal cells commit to myogenesis before adapting a muscle stem cell state, and then a lateral inhibition mechanism initiated by the differentiating cells controls the simultaneous production of functional muscle and the maintenance of the stem cell pool. Image published in: Nogueira JM et al. (2015) Copyright © 2015 Meireles Nogueira, Hawrot, Sharpe, Noble, Wood, Jorge, Goldhamer, Kardon and Dietrich. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |