Xenbase Image ID: 145167

Fig. 4. ERF or ETV3/3L knockdown inhibits the neural differentiation pathway. Embryos were injected unilaterally at the two- or four-cell stage. The injected side is indicated by the magenta lineage tracer. (A,D,G,J) Control expression of N-tubulin, Myt1, Dl1 and Ngnr1. (B,E,H,K) Embryos injected with 20 ng Erf MO showed reduction of N-tubulin (18/19), Myt1 (11/13), Dl1 (8/10) and Ngnr1 (10/11). (C,F,I,L) Embryos injected with 20 ng Etv3/3l AUG MO showed reduction of N-tubulin (23/25), Myt1 (19/20), Dl1 (38/44) and Ngnr1 (20/26). Embryos are shown in dorsal view at stage 14; anterior is at the bottom. Red arrows indicate areas where neural fold elevation is reduced (see supplementary material Fig. S9). Image published in: Janesick A et al. (2013) Copyright © 2013. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue tubb2b.S N-Tub, n-tubulin, NBT, neural beta-tubulin, NST, ntubulin, Xn-tubulin X. laevis Throughout NF stage 14 neuron myt1.L X-MyT1, xmyt1, XMyTI X. laevis Throughout NF stage 14 neuron dll1.L delta-1, Delta-1, delta1, x-delta, X-delta-1, Xdelta-1, Xdelta1, XDelta1 X. laevis Throughout NF stage 14 neuron neural plate border pre-chordal neural plate border neurog2.L atoh4, neurog2-a, neurog2-b, neurogenin 2, neurogenin-2, neurogenin-related-1, neurogenin2, ngn-2, ngn2, ngnr, ngnr 1a, Ngnr-1, Ngnr1, X-ngnr-1, xngn2, Xngnr-1, XNgnr1 X. laevis Throughout NF stage 14 neuron preplacodal ectoderm anterior placodal area Image source: Published Larger Image Printer Friendly View

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