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Fig. 5. Model for the mechanism of the switch off in Shh canonical signaling during spinal cord development. The transition from neural plate to spinal cord is accompanied by the appearance of Ca2+ spikes, which intercalate in the Shh-signaling pathway to down-regulate Gli activity. This switch off of the canonical Shh pathway is implemented at several levels including regulation of Gli subcellular localization, posttranslational processing, and transcriptional repression, all converging in inhibiting Gli activity. Image published in: Belgacem YH and Borodinsky LN (2015) Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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