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Figure 5. CNGA3-T153M polymorphism decreases the maximum open probability for heteromeric but not homomeric CNG channels. (A) Current-variance plot for A3T153M homomeric (open circles) and A3T153M+B3 (closed circles) channels following activation by various concentrations cGMP at +80 mV (as in Figure 3). Continuous lines were produced by fitting with a 2nd-order polynomial using the following best-fit parameters: A3T153M (solid), i = 2.5 pA, N = 370 channels; A3T153M+B3 (hashed), i = 2.5 pA, N = 370 channels. Arrows denote mean variance at saturating cGMP for A3T153M (solid) and A3T153M+B3 (hashed). (B) Maximum open probability was decreased for heteromeric A3T153M+B3, but not homomeric A3T153M channels compared to wild-type channels (***p < 0.001, Student's t-test, n = 4–8). Image published in: Meighan PC et al. (2015) Copyright © 2015 Meighan, Peng and Varnum. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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