Xenbase Image ID: 145477

FIG. 4. Misexpresslon of Xwnt-8 in the dorsal mesoderm results in the loss of both forebrain mad mldbram. Untreated embryos (A-C) or embryos made to misexpress Xwnt-8 in the dorsal mesoderm during gastrulation (D-I) were cultured to tailbud stage and hybridized with digoxygeninlabeled X-dll3, Xwnt-8b, and Xotx-2 probes as indicated above each column. All embryos are oriented with anterior to the left, and dorsal toward the top of the figure. (A) X-dlI3 staining of branchial arches (small black arrows), ouc (large black arrow) and olfactory (black arrowhead) placodes, telencephalon (open black arrow), and ventral diencephalon (open white arrow) is indicated. Staining of the ventral diencephalon is partially out of the plane of focus in this figure and thus appears reduced relative to that shown in Fig. 2A. (B} Arrow denotes staining of the dorsal diencephalon and arrowhead indicates staining of cells at the forebram-midbram boundary following hybndizatlon with an Xwnt-Sb probe. (C) Xotx-2 staining of the telencephalon (open black arrow), and the rnidbrain (between filled arrows) is indicated. Image published in: Fredieu JR et al. (1997) Copyright © 1997. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue wnt8b.S LOC108696239, wnt-8b, Xwnt-8b, xwnt8b X. laevis Throughout NF stage 32   otx2.S otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 32 midbrain dlx5.L dll3, X-dll3 X. laevis Throughout NF stage 32 forebrain pharyngeal arch Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + wnt8b + NF29/30 (in situ hybridization) Fig.4.d Expression Phenotype decreased amount dlx5.L expression in head Xla Wt + wnt8b + NF29/30 (in situ hybridization) Fig.4.e Expression Phenotype decreased amount wnt8b.S expression in head Xla Wt + wnt8b + NF29/30 (in situ hybridization) Fig.4.f Expression Phenotype decreased amount otx2.L expression in head Xla Wt + wnt8b + NF29/30 (in situ hybridization) Fig.4.g Expression Phenotype decreased amount dlx5.L expression in head Xla Wt + wnt8b + NF29/30 (in situ hybridization) Fig.4.h Expression Phenotype decreased amount wnt8b.S expression in head Xla Wt + wnt8b + NF29/30 (in situ hybridization) Fig.4.i Expression Phenotype decreased amount otx2.L expression in head Larger Image Printer Friendly View

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