Xenbase Image ID: 145572

Fig. 5. Cell proliferation is decreased in MTX treated embryos. (A) Schematic of the experimental design. (B) Immunohistochemistry of pH3 in representative transverse sections of the face from embryos treated with DMSO (i), or MTX (ii, iii). Images are all at the same magnification, scale bar=100 μm. (C) FACS analysis of the cell cycle. (i) Representative cell cycle profiles. (ii) The average percentages of cells in each fraction from 4 experiments. Statistical significance was determined using Mann Whitney U test and designated by asterisks (p values≤0.028). Image published in: Wahl SE et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue h3-3a.L h3.3, h3.3a, h3f3a X. laevis Throughout NF stage 35 and 36 mitotic cell head Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + Methotrexate Hydrate + NF35/36 (immunohistochemistry) fig.5.b. ii, iii Anatomical Phenotype obsolete abnormal histone phosphorylation Larger Image Printer Friendly View

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