Xenbase Image ID: 145574

Fig. 7. Mechanism of folate and retinoic acid signaling interaction. (A, B) Representative transverse sections through the face labeled with cleaved caspase-3 (green) and counterstained with propidium iodide. This was consistent in at least 10 embryos at equivalent locations in the face All images were taken at the same magnification, scale bar=175 μm. (D) Model of how folinic acid supplementation prevents median orofacial clefts. (E) Model of the mechanism by which RAR and DHFR inhibition could synergize. Image published in: Wahl SE et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Experiment + Assay Source Phenotypes and Disease Xla Wt + BMS453 + NF35/36 (immunohistochemistry) fig.7.b, c Anatomical Phenotype increased apoptosis in head Larger Image Printer Friendly View

Return to previous page