XB-IMG-145947
Xenbase Image ID: 145947
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Distinct Cdx effect on known targets and 2R paralogues. Fold-change in expression induced by different Cdx MOs, or by triple Cdx MO injection, is indicated using a blue (down) to red (up) colour scale for each gene. a, b Schematized Hox gene clusters in X. tropicalis showing effects of Cdx gene knockdown on expression levels. Effects of Cdx4 (a) and triple injection (b) shown. Genes in grey are below expression cut-off (FPKM<2). c Fold-change in Hox gene expression caused by triple MO injection plotted against paralogy group assignment; each data point represents one Hox gene. Only genes with statistically significant change in expression are included. Colours denote anterior (red), middle (green), and posterior (blue) paralogy group assignments, assigning group 3 to anterior. d, e Heatmap representation of MO effect on Cdx target gene pathways: Fgf genes, Wnt genes, Retinoic acid pathway. Only genes expressed at stage 14 (FPKM>2) are included. g Effect of Cdx genes on pairs or triplets of genes originated through 2R vertebrate genome duplication (see Methods) which show differential regulation by distinct Cdx paralogues. Significance of differential expression is denoted by one (P <0.05) or two (P <0.005) asterisks (a, b, d–g) Image published in: Marlétaz F et al. (2015) © Marlétaz et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |