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Fig 5. Absence of Pkdcc1 and Pkdcc2 does not change cell fate of mesoderm and neural tissues. Whole mount in situ hybridization for Xbra (A-C) and chd (D-F) of embryos injected with CoMo (A, D), pkdcc1Mo (B, E) or pkdcc2Mo (C, F) in the dorsal blastomeres. Whole mount in situ hybridization for myoD (G-I), slug (J-L), epk/chd (M-O), otx2 (P-R) and sox2 (S-U) of embryos injected with CoMo (G, J, M, P, S), pkdcc1Mo (H, K, N, Q, T) or pkdcc2Mo (I, L, O, R, U) in the right side. (A-F) Vegetal view of gastrula stage embryos with dorsal to the top. (G-U) Anterior view of embryos from late gastrula (G-I) to neurula stages (J-U) with dorsal to the top. inj, injected side; co, uninjected side. Image published in: Vitorino M et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 15 neural crest chordal neural plate border tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 10 mesoderm marginal zone chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 11 mesoderm dorsal marginal zone involuting marginal zone upper blastopore lip myod1.S mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Throughout NF stage 14 mesoderm paraxial mesoderm krt12.4.L ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. laevis Throughout NF stage 15 non-neural ectoderm ectoderm epidermis chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 15 notochord otx2.S otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 15 pre-chordal neural plate sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 15 neural plate neuroectoderm Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + pkdcc.1 MO + neurula stage (in situ hybridization) fig.5.h, k, n, q, t Anatomical Phenotype abnormally delayed closure of neural tube Xla Wt + pkdcc.2 MO + neurula stage (in situ hybridization) fig.5.i, l, o, r, u Anatomical Phenotype abnormally delayed closure of neural tube Larger Image Printer Friendly View

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