Xenbase Image ID: 146113

Figure 2. Two models for formation of cone-shaped OSs. Dend2 protein is shifted from green to red fluorescent isoform by photoconversion. After photoconversion, newly synthesized Dend2 protein is green and is added to the base of the OS in of both the models. A: In model A, the cone shape is formed by the retrograde trafficking of protein from older to newer disks. Shortly after photoconversion, newly synthesized green Opsin-Dend2 is added to the evaginations formed before the photoconversion to form new disks, therefore, a few disks contain both green (new) and red (older) proteins generating yellow fluorescence (red + green = yellow). Due to the retrograde trafficking of Opsin-Dend2, the number of disks with both old and new protein increases over time after photoconversion. B: The cone shape is formed by the addition of gradually larger disks at the base of the OS. There is no trafficking between disks as indicated by a clear separation of proteins before and after photoconversion. Image published in: Tian G et al. (2014) Copyright © 2014. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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