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Fig. 4. Snail2 requires EZH2 to regulate neural crest markers. Snail2 RNA (0.15 ng) was injected alone or with 20 ng EZH2-MO unilaterally into two-cell-stage embryos. ISH performed at neurula stages 17-18 revealed that ectopic expression of Snail2 expanded domains of neural crest genes Snail2, Sox9, Sox10 and Twist. However, Snail2 failed to expand the domains of these genes in the presence of EZH2-MO, implying that neural crest expansion by Snail2 required EZH2 function. The numbers of embryos showing the displayed patterns over total embryos analyzed are shown. Image published in: Tien CL et al. (2015) Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 18 neural crest cranial neural crest sox9.S cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 18 anterior placodal area neural crest cranial neural crest trunk neural crest sox10.L X. laevis Throughout NF stage 18 neural crest cranial neural crest trunk neural crest twist1.S twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 18 neural crest cranial neural crest Image source: Published Larger Image Printer Friendly View

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