XB-IMG-146173
Xenbase Image ID: 146173
Fig. 8. Model illustrating ELMO-DOCK1-Rac1 and their interaction with Ezrin and the effects on basal body migration and spacing in MCCs. (A) The ELMO-DOCK1 complex localises to the ciliary basal body and acts as bipartite guanine nucleotide exchange factor for Rac1. Rac1 in turn dephosphorylates Ezrin via an unknown phosphatase (PPase). Dephosphorylated Ezrin does not bind to actin filaments, whereas phosphorylated Ezrin serves as a linker between the basal body and actin filaments. (B) Constant turnover of phosphorylated Ezrin regulated by ELMO-DOCK1-Rac1 is necessary to promote basal body migration along actin filaments (arrows) and for basal body docking to the membrane and spacing (double arrows) with assembly of the apical and subapical actin network. Image published in: Epting D et al. (2015) Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |