Xenbase Image ID: 146514

Figure 8. SOX7, SOX18, and the cardiogenic pathway: In this diagram, direct interactions are indicated by solid lines, indirect interactions by dotted lines. SOX17 induces Xnr4, but fails to induce cardiogenesis in animal caps, whereas SOX7 and SOX18 induce both Xnr2 and Xnr4 and induce cardiogenesis. The presence of the nodal inhibitor CerS inhibits SOX7 and SOX18-induced cardiogenesis. How other direct and indirect targets of SOX7 and SOX18 interact with “downstream” targets of Xnr-regulation (e.g., Eomes, Wnt11, Cerberus, and Hex) remains unclear; nevertheless, the end result in the activation of Nkx2.5 and other cardiac markers by SOX7 and SOX18. Image published in: Zhang C et al. (2005) Copyright © 2005. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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