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Figure 10. Model illustrating YAP function in retinal stem cells.We found that YAP is expressed in CMZ retinal stem cells (left panel). The middle panel shows the cell cycle of wild type retinal stem cells and the putative role of the YAP/PKNOX1 complex in the control of S-phase temporal progression (represented by the distinct patterns of DNA replication foci). YAP knock-down (right panel) leads to a dramatic reduction of S-phase length likely due to c-Myc-dependent premature firing of late replication origins. This results in increased occurrence of DNA damage, enhanced p21 and p53 expression and eventually cell death.DOI: http://dx.doi.org/10.7554/eLife.08488.018 Image published in: Cabochette P et al. (2015) © 2015, Cabochette et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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