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FIGURE 9. Proposed model showing Ets1 regulation of BMP signal and NC formation through Hdac1. When ets1 is overexpressed in embryos, it binds to Hdac1, and recruits Hdac1 to the id3 promoter, leading to deacetylation of histone and chromatin condensation, which prevents transcription of id3 and causes inhibition of NC formation. Other BMP targets involved in NC development may also be affected by this mechanism. When ets1F3 or ets1F4 Ets1 mutant is overexpressed, it enhances histone acetylation of id3 promoter and therefore promotes NC formation. eF3, Ets1F3; Ac, acetyl group; P-Smad, phosphorylated Smad. Image published in: Wang C et al. (2015) Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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