Xenbase Image ID: 147933

Figure 2. Embryos microinjected with Xdd1 mRNA develop a specific morphogenetic defect. Two-cell embryos were injected dorsally with 1 ng of each mRNA into each blastomere. (a) Stage 14 neurulae injected with Xdd1 mRNA (on the right) and with Xdd2 mRNA (on the left). Note the failure of neural folds (shown by two small white arrowheads) to close into a neural tube. The cement gland develops at the anterior end (large arrowhead); the closed blastopore is visible at the posterior end. The embryo injected with Xdd2 mRNA has a normal neural tube and is indistinguishable from uninjected embryos and from embryos injected with wild-type Xdsh (not shown). (b) Stage 40 tadpoles. Top: control embryo (uninjected); bottom: Xdd1-injected embryos with posterior deficiencies. (c) Sagittal histological section of Xdd1-injected embryo (stage 40); (d) sagittal section of a control embryo (stage 40). Abbreviations: m, muscle; nc, notochord; nt, neural tissue; cg, cement gland. The bar in (d), which also refers to (c), is 200μm. Image published in: Sokol SY (1996) Copyright © 1996. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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