Xenbase Image ID: 148221

Figure 3. Evolutionary analyses of the miR-1/206 family regulatory network.(A) The phylogenetic tree of miR-1/206 family. This tree was drawn by MEGA 5.2.2 (Neighbor-Joining algorithm, 500 bootstrap replications) [42]. Blue: the branch of miR-1 subfamily; light blue: miR-206 subfamily. This tree shows that miR-1 subfamily existed before C. elegans and miR-206 subfamily before D. rerio. (B) The regulatory network of the miR-1/206 family in humans. The miR-1/206 family is represented by an octagon in the center of the network. Circles denote target genes of miR-1/206 in humans. Circle colors denote the most distant species in which the gene was targeted by the miR-1/206 family. The representative enriched functions specific to each species are listed under each species name. (C) The correlation between the Gene Ontology (GO) level of the top 10 enriched functions in miR-1/206 human target genes and the evolutionary distance. Target genes of older species tend to be enriched with more general biological functions, represented by lower levels of GO terms. (Mya: Million Years Ago). Image published in: Lin CC et al. (2014) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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