Xenbase Image ID: 148420

Fig. 8. Morpholinos against candidate neurogenic genes generate a range of neurogenesis phenotypes. Summary of the in vivo imaging data showing the numbers of GFP-labeled cells generated over time (A), the proportion of the cells that were neurons (B) or NPCs (C) for each experimental condition. (A) The genes targeted with morpholinos are arranged by the magnitude of the change in cell number over 3 days. The asterisks indicate a significant decrease or increase compared to control morpholino conditions (red line). The mean values, SEMs and p-values are in Table 4. (B–C) The proportion of neurons (B) and NPCs (C) as a percentage of all cells counted on day 3. The genes targeted are listed along the y-axis and arranged by those that produced the greatest proportion of neurons. Asterisks indicate differences in the proportion of cell types between the experimental and matched control morpholino groups (Mann–Whitney U test, p<0.05). Gene symbols listed in red identify the morpholinos that resulted in a significant difference in the proportions of cell types compared to control (Pearson X-square test, p<0.05). The mean values, SEMs and p-values are in Table 2. Red lines on graphs indicate the mean control morpholino (conMO) values for the proportion of neurons or NPCs. The mean values, SEMs, and p-values are in Table 5. Image published in: Bestman JE et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Experiment + Assay Source Phenotypes and Disease Xla Wt + actn1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + arl9 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + armc8 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + chn1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + cpeb1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + ctdnep1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + elk4 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + ephb1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + fgf2 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + fmr1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + fxr1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + glis2 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + gstp1 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + hdac6 MO + NF48 (morphology) Fig.8.A Anatomical Phenotype abnormal development of optic tectum abnormally decreased number of neural progenitor cell Xla Wt + hspa5 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + lsm6 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + mmp9 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + mocs3 MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype increased cell population proliferation in optic tectum Xla Wt + prkaca MO + NF47-48 (morphology) Fig.8.A Anatomical Phenotype decreased cell population proliferation in optic tectum Xla Wt + armc8 MO + NF47-48 (morphology) Fig.8.B-C Anatomical Phenotype abnormal development of optic tectum abnormally decreased number of neural progenitor cell abnormally increased number of neuron Xla Wt + chn1 MO + NF48 (morphology) Fig.8.B-C Anatomical Phenotype abnormal development of optic tectum abnormally decreased number of neural progenitor cell Xla Wt + gstp1 MO + NF48 (morphology) Fig.8.B-C Anatomical Phenotype abnormal development of optic tectum abnormally decreased number of neural progenitor cell abnormally increased number of neuron Xla Wt + hspa5 MO + NF48 (morphology) Fig.8.B-C Anatomical Phenotype abnormal development of optic tectum abnormally decreased number of neuron abnormally increased number of neural progenitor cell Larger Image Printer Friendly View

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