XB-IMG-148429
Xenbase Image ID: 148429
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Fig. 7. Schematic diagram showing a feedback loop of pou5f3.2
and Nodal. Nodal signaling activates the gene expression of
pou5f3.2, which in turn inhibits the Nodal signaling. Such a feedback
loop might play a role in maintaining the moderate expression
of pou5f3.2. Consequently, pou5f3.2 is able to keep cells in
proliferative state instead of cell differentiation through the downregulation
of Nodal and p27Xic1. Image published in: Nishitani E et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View |