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Fig. 1. KCNE1 overexpression induces hyperpigmentation. (A) Microinjection of KCNE1 mRNA at the one-cell stage induces 32% of embryos grown to stage 45 to exhibit hyperpigmentation compared with controls (<2%). (B) Controls. (C) Hyperpigmented embryos have far more melanocytes in the head but very normal overall development. Yellow rectangle indicates region in which melanocytes were counted (Table 1). (Magnifications: B and C, ×9.) Image published in: Morokuma J et al. (2008) Copyright © 2008. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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