XB-IMG-148475
Xenbase Image ID: 148475
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Fig. S3. Hyperpigmentation can be induced even after neural crest specification. (A) A wild-type embryo (control) at stage 45. (B) A typical hyperpigmented
embryo (induced by KCNE1 overexpression), photographed here without tricaine, which causes the pigment granules in each cell to contract into the center,
facilitating counting (used in Fig. 1). Larvae exposed to Chromanol 293B (a specific blocker ofKCNQ1channels) at stage 41 acquired a hyperpigmented phenotype
within 6 days of culture, first in the region overlying the hindbrain (C, blue arrow) and then spreading throughout the head (D, red arrows indicate ectopic
melanocytes in the periocular region). Image published in: Morokuma J et al. (2008) Copyright © 2008. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |