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Clutch A vs Clutch B PolyA+ Differential Expression
A – Clutch A vs Clutch B histogram of differential expression scores as measured by the Bayesian Information Criterion (BIC), larger scores indicate greater differential expression (Supplemental Experimental Procedures). Three regions marked: 1) no differential expression BIC ≤ 0, 2) differential expression small effect 0 < BIC ≤ 60, 3) differential expression large effect BIC > 60. See B for explanation of thresholds.
B – Differential expression effect size as measured by the log10 mean overlap between Clutch A and Clutch B Gaussian process models (Supplemental Experimental Procedures). Mean overlap decreases with increasing BIC. BIC = 0, 60 and mean overlaps of 60%, 10% and 2.5% marked. At BIC = 60 approximately all genes have less than 10% overlap, and all genes with less than 2.5% overlap have BIC > 60.
C – Differential expression examples with decreasing BIC (top right). Genes on the boundary for strong differential expression have highly correlated expression profiles in A and B. Vertical lines mark convergences (red) or divergences (black).
D – Left: Examples of convergence (dhx32) and divergence (Xetro.K05169). Right: Histogram of convergence and divergence times.
Image published in: Owens ND et al. (2016)
Copyright © 2016. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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