Xenbase Image ID: 149110

Fig. 1. Two major Wnt pathway branches.The canonical Wnt/-catenin pathway antagonizes the -catenin destruction complex, consisting of Axin, GSK3 and APC to promote target gene transcription. By contrast,the Wnt/PCP pathway is thought to involve Frizzled/Dishevelled signaling to locally activate RhoA, ROCK and Myosin II and, at the same time, precludes the recruitment ofVangl2/Prickle to the same membrane subdomain. Roles of the vertebrate PCP proteins Fuzzy, Inturned and Diversin in PCP are unclear. Besides the mutually antagonisticinteractions inside the cell, PCP is coordinated by the positive feedback between the Frizzled/Dishevelled complex and the Vangl2/Prickle complex across the cell junction.Two neighboring epithelial cells are shown. Image published in: Sokol SY (2015) Copyright © 2015. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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